dr mohamed saker posts
*alpha 1 agonist contra'indicated in cardiogenic shock due to present of decreasing blood flow to organs and alpha 1 agonist make vasoconstriction decreasing blood flow to organs .
* septic shock is presence of infection in the bovy making release of inflammatory madiators making severe vasodilation making hypotension must give alpha 1 agonist to make vasoconstriction and increasing blood pressure
* betablocker treatment hypertension due to blocking beta 1 receptor in the heart making decreasing in heart rate + decreasing cardiac output and blocking of bata 1 receptor in the kidney juxtaglomerular cells decreasing renin and decreasing angiotensin II make V.D + blocking of beta 2 receptor in the sympathetic nerve decreasing NA release + inhibit sympathetic outflow centrally from sympathetic center
* use carvidelol , metoprolol , bisoprolol in treatment of heart failure due to prevention of excessive sympathetic discharge on the heart + carvidelol making alpha blocker activity making V.D in artery and veins making decreasing afterload and preload making resting of heart
* All drugs acting selectively on enzyme , ion channel , carrier , receptor EXCEPT general anaesthetic and alcohol .
* addition of antagonist to agonist shift log dose - response curve to the right .
* ارقام vd
* NE making incresaing of P.R by activation of alpha receptor in the blood vessels making increasing of B.P leads to activation of baroreceptor activate cardiac inhibitory center releasing of acetylcholine from vagus nerve making bradycardia -ve chronotropic effect هامة جداااااااااااااااااااااااااااا
امتحان+epinephrine making activation of beta 2 receptor in the blood vessel more than alpha1 receptor making vasodilation more than vasoconstriction leads to decreasing total P.R leads to decreasing B.P .
* Epinephrine in large dose making activation of alpha1 more than beta2 making vasoconstriction leads to increasing of diastole in large dose only .
epinephrine large dose making reflex bradycardia like norepinephrine .
* fermented food like old cheese containing of tyramine making increase of releas of NA from sympathetic nerve and MAO enzyme break it but if you taking MAO inhibitor with tyramine containg food making hypertensive crisis due to accumulation of NA without breakdown of it .
* stable angina is effort angina cause due to atherosclerosis in coronary arteries making loss of elasticity in coronaries when exert effort increasing heart work with no increase in oxygen blodd supply from coronaries leadsto pain of angina to treatment it give beta blocker to block beta1 receptor in the heart to make decreasing heart work to prevent occuranceof angina .
* variant angina has not atherosclerosis making by vasoconstriction of lcoronary artery during rest must treatment by vasodilator like ca+2 channel blocker + nitrates and contra'indicated use of beta blocker due to block beta 2 receptor in the coronaries making predominates effect of alpha 1 receptor in the blood vessel making vasoconstriction of coronaries making increase in angina symptoms .
هو ليه ال alpha 1 agonists بنستخدمها في علاج ال cardiogenic we septic shock we el hypovalemic la2 :Sabout an hour ago
ويعني ايه septic aslan ?
سؤال تانى بقي في البلوكير بتاعة ال beta
ازاي بتعالج ال hypertension
وازاي ال selctive beta 1 blocker بنستخدمها في علاج ال heart failure ؟
ياريت اللى فاهم يفهمني :(((
Ahmed Ibrahim likes this.
ياريت نجمع الاختصارات هنا عشان انا اتعقدت منهم